4KV4

Brd4 Bromodomain 2 in Complex with Acetylated Rel Peptide

Summary for 4KV4

• Entry DOI: 10.2210/pdb4kv4/pdb
• Related: 4KV1
• Descriptor: Bromodomain-containing protein 4, Rel Peptide, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... (4 entities in total)
• Functional Keywords: rel, p65, bromodomain, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: O60885 Q04206
• Total number of polymer chains: 2
• Total formula weight: 13929.29

Authors

Zhang, H.,Nair, S.K. (deposition date: 2013-05-22, release date: 2013-06-26, Last modification date: 2014-05-14)

• Primary citation: Zou, Z.,Huang, B.,Wu, X.,Zhang, H.,Qi, J.,Bradner, J.,Nair, S.,Chen, L.F.; Brd4 maintains constitutively active NF-kappa B in cancer cells by binding to acetylated RelA.; Oncogene, 33:2395-2404, 2014; PubMed: 23686307; DOI: 10.1038/onc.2013.179

Experimental method

X-RAY DIFFRACTION (2 Å)