4KV1

Crystal Structure of Brd4 Bromodomain 1 in Complex with Acetylated Rel Peptide

Summary for 4KV1

• Entry DOI: 10.2210/pdb4kv1/pdb
• Related: 4KV4
• Descriptor: Bromodomain-containing protein 4, Rel peptide (3 entities in total)
• Functional Keywords: rel, p65, bromodomain, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: O60885 Q04206
• Total number of polymer chains: 4
• Total formula weight: 32135.14

Authors

Zhang, H.,Nair, S.K. (deposition date: 2013-05-22, release date: 2013-06-26, Last modification date: 2014-05-14)

• Primary citation: Zou, Z.,Huang, B.,Wu, X.,Zhang, H.,Qi, J.,Bradner, J.,Nair, S.,Chen, L.F.; Brd4 maintains constitutively active NF-kappa B in cancer cells by binding to acetylated RelA.; Oncogene, 33:2395-2404, 2014; PubMed: 23686307; DOI: 10.1038/onc.2013.179

Experimental method

X-RAY DIFFRACTION (1.5 Å)