4KP8

Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with 3-[(Pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide

Summary for 4KP8

Entry DOI	10.2210/pdb4kp8/pdb
Related	4KNI 4KNJ 4KNM 4KNN 4KP5
Descriptor	Carbonic anhydrase 12, ZINC ION, 3-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide, ... (7 entities in total)
Functional Keywords	drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: O43570
Total number of polymer chains	4
Total formula weight	121211.44
Authors	Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2013-05-13, release date: 2013-11-06, Last modification date: 2023-11-08)
Primary citation	Capkauskaite, E.,Zubriene, A.,Smirnov, A.,Torresan, J.,Kisonaite, M.,Kazokaite, J.,Gylyte, J.,Michailoviene, V.,Jogaite, V.,Manakova, E.,Grazulis, S.,Tumkevicius, S.,Matulis, D. Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII Bioorg.Med.Chem., 21:6937-6947, 2013 Cited by PubMed: 24103428 DOI: 10.1016/j.bmc.2013.09.029 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation