4KNB

C-Met in complex with OSI ligand

Summary for 4KNB

• Entry DOI: 10.2210/pdb4knb/pdb
• Descriptor: Hepatocyte growth factor receptor, 7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine, GAMMA-BUTYROLACTONE, ... (4 entities in total)
• Functional Keywords: protein kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
• Total number of polymer chains: 4
• Total formula weight: 132419.11

Authors

Wang, J.,Steinig, A.G.,Li, A.H.,Chen, X.,Dong, H.,Ferraro, C.,Jin, M.,Kadalbajoo, M.,Kleinberg, A.,Stolz, K.M.,Tavares-Greco, P.A.,Wang, T.,Albertella, M.R.,Peng, Y.,Crew, L.,Kahler, J. (deposition date: 2013-05-09, release date: 2014-04-30, Last modification date: 2024-02-28)

• Primary citation: Steinig, A.G.,Li, A.H.,Wang, J.,Chen, X.,Dong, H.,Ferraro, C.,Jin, M.,Kadalbajoo, M.,Kleinberg, A.,Stolz, K.M.,Tavares-Greco, P.A.,Wang, T.,Albertella, M.R.,Peng, Y.,Crew, L.,Kahler, J.,Kan, J.,Schulz, R.,Cooke, A.,Bittner, M.,Turton, R.W.,Franklin, M.,Gokhale, P.,Landfair, D.,Mantis, C.,Workman, J.,Wild, R.,Pachter, J.,Epstein, D.,Mulvihill, M.J.; Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases.; Bioorg.Med.Chem.Lett., 23:4381-4387, 2013; PubMed: 23773865; DOI: 10.1016/j.bmcl.2013.05.074

Experimental method

X-RAY DIFFRACTION (2.4 Å)