4KD1
CDK2 in complex with Dinaciclib
Summary for 4KD1
| Entry DOI | 10.2210/pdb4kd1/pdb |
| Descriptor | Cyclin-dependent kinase 2, 1,2-ETHANEDIOL, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, ... (4 entities in total) |
| Functional Keywords | protein kinase, dinaciclib, transferase-transferase, cell cycle-inhibitor complex, cell cycle/inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 |
| Total number of polymer chains | 1 |
| Total formula weight | 34436.05 |
| Authors | Martin, M.P.,Schonbrunn, E. (deposition date: 2013-04-24, release date: 2013-09-18, Last modification date: 2023-09-20) |
| Primary citation | Martin, M.P.,Olesen, S.H.,Georg, G.I.,Schonbrunn, E. Cyclin-dependent kinase inhibitor dinaciclib interacts with the acetyl-lysine recognition site of bromodomains. Acs Chem.Biol., 8:2360-2365, 2013 Cited by PubMed: 24007471DOI: 10.1021/cb4003283 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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