4KB6

Structure of porcine cyclic GMP AMP synthase (CGAS) in complex with DNA, ATP and GTP

Summary for 4KB6

• Entry DOI: 10.2210/pdb4kb6/pdb
• Related: 4JLX 4JLZ
• Descriptor: Uncharacterized protein, DNA (5'-D(P*CP*GP*AP*CP*GP*CP*TP*AP*GP*CP*GP*TP*CP*G)-3'), ZINC ION, ... (7 entities in total)
• Functional Keywords: oas-like fold, receptor, immunity, cgas, double stranded dna, gtp, cytosol, transferase-dna complex, transferase/dna
• Biological source: Sus scrofa (pigs,swine,wild boar); More
• Cellular location: Cytoplasm, cytosol : I3LM39
• Total number of polymer chains: 3
• Total formula weight: 52153.82

Authors

Deimling, T.,Hopfner, K.-P. (deposition date: 2013-04-23, release date: 2013-06-05, Last modification date: 2023-09-20)

• Primary citation: Civril, F.,Deimling, T.,de Oliveira Mann, C.C.,Ablasser, A.,Moldt, M.,Witte, G.,Hornung, V.,Hopfner, K.P.; Structural mechanism of cytosolic DNA sensing by cGAS.; Nature, 498:332-337, 2013; PubMed: 23722159; DOI: 10.1038/nature12305

Experimental method

X-RAY DIFFRACTION (3.0754 Å)