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Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppdG(2 ,5 )pdG

Summary for 4K99

Related4K96 4K97 4K98 4K8V 4K9A 4K9B
DescriptorCyclic GMP-AMP synthase (E.C.2.7.7.-)/DNA
Functional Keywordsnucleotidyltransferase fold, TRANSFERASE-DNA complex,TRANSFERASE/DNA
Biological sourceMus musculus (mouse)
Cellular locationCytoplasm, cytosol Q8C6L5
Total number of polymer chains3
Total molecular weight53893.82
Gao, P.,Wu, Y.,Patel, D.J. (deposition date: 2013-04-19, release date: 2013-05-15, modification date: 2013-08-28)
Primary citation
Gao, P.,Ascano, M.,Wu, Y.,Barchet, W.,Gaffney, B.L.,Zillinger, T.,Serganov, A.A.,Liu, Y.,Jones, R.A.,Hartmann, G.,Tuschl, T.,Patel, D.J.
Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Cell(Cambridge,Mass.), 153:1094-1107, 2013
PubMed: 23647843
DOI: 10.1016/j.cell.2013.04.046
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.203704.3%2.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

no rotation
rotated about x axis by 90°
rotated about y axis by 90°
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entries available on 2015-03-25
00:00 UTC / 09:00 JST