4K6I

Crystal structure of human retinoid X receptor alpha-ligand binding domain complex with Targretin and the coactivator peptide GRIP-1

Summary for 4K6I

• Entry DOI: 10.2210/pdb4k6i/pdb
• Related: 1MVC 3OAP 4K4J
• Descriptor: Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid, ... (4 entities in total)
• Functional Keywords: ligand binding domain, cancer, targretin (bexarotene), transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : P19793 Q15596
• Total number of polymer chains: 2
• Total formula weight: 27825.37

Authors

Xia, G.,Smith, C.D.,Muccio, D.D. (deposition date: 2013-04-15, release date: 2013-11-13, Last modification date: 2023-09-20)

• Primary citation: Boerma, L.J.,Xia, G.,Qui, C.,Cox, B.D.,Chalmers, M.J.,Smith, C.D.,Lobo-Ruppert, S.,Griffin, P.R.,Muccio, D.D.,Renfrow, M.B.; Defining the Communication between Agonist and Coactivator Binding in the Retinoid X Receptor alpha Ligand Binding Domain.; J.Biol.Chem., 289:814-826, 2014; PubMed: 24187139; DOI: 10.1074/jbc.M113.476861

Experimental method

X-RAY DIFFRACTION (2.1 Å)