4K5Y
Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395
Summary for 4K5Y
Entry DOI | 10.2210/pdb4k5y/pdb |
Related | 3EHS 3EHT 3EHU |
Descriptor | Corticotropin-releasing factor receptor 1, T4-Lysozyme chimeric construct, 3,6-dimethyl-N-(pentan-3-yl)-2-(2,4,6-trimethylphenoxy)pyridin-4-amine, OLEIC ACID, ... (8 entities in total) |
Functional Keywords | 7tm, gpcr, family b, signalling protein, g-protein, membrane, membrane protein, receptor |
Biological source | HOMO SAPIENS (human) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P34998 |
Total number of polymer chains | 3 |
Total formula weight | 156772.32 |
Authors | Hollenstein, K.,Kean, J.,Bortolato, A.,Cheng, R.K.Y.,Dore, A.S.,Jazayeri, A.,Cooke, R.M.,Weir, M.,Marshall, F.H. (deposition date: 2013-04-15, release date: 2013-07-17, Last modification date: 2023-09-20) |
Primary citation | Hollenstein, K.,Kean, J.,Bortolato, A.,Cheng, R.K.,Dore, A.S.,Jazayeri, A.,Cooke, R.M.,Weir, M.,Marshall, F.H. Structure of class B GPCR corticotropin-releasing factor receptor 1. Nature, 499:438-443, 2013 Cited by PubMed: 23863939DOI: 10.1038/nature12357 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.977 Å) |
Structure validation
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