Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4K5Y

Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395

Summary for 4K5Y
Entry DOI10.2210/pdb4k5y/pdb
Related3EHS 3EHT 3EHU
DescriptorCorticotropin-releasing factor receptor 1, T4-Lysozyme chimeric construct, 3,6-dimethyl-N-(pentan-3-yl)-2-(2,4,6-trimethylphenoxy)pyridin-4-amine, OLEIC ACID, ... (8 entities in total)
Functional Keywords7tm, gpcr, family b, signalling protein, g-protein, membrane, membrane protein, receptor
Biological sourceHOMO SAPIENS (human)
More
Cellular locationCell membrane; Multi-pass membrane protein: P34998
Total number of polymer chains3
Total formula weight156772.32
Authors
Hollenstein, K.,Kean, J.,Bortolato, A.,Cheng, R.K.Y.,Dore, A.S.,Jazayeri, A.,Cooke, R.M.,Weir, M.,Marshall, F.H. (deposition date: 2013-04-15, release date: 2013-07-17, Last modification date: 2023-09-20)
Primary citationHollenstein, K.,Kean, J.,Bortolato, A.,Cheng, R.K.,Dore, A.S.,Jazayeri, A.,Cooke, R.M.,Weir, M.,Marshall, F.H.
Structure of class B GPCR corticotropin-releasing factor receptor 1.
Nature, 499:438-443, 2013
Cited by
PubMed: 23863939
DOI: 10.1038/nature12357
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.977 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon