4K4J

Crystal structure of human Retinoid X Receptor alpha-ligand binding domain complex with 9cUAB30 and the coactivator peptide GRIP-1

Summary for 4K4J

Entry DOI	10.2210/pdb4k4j/pdb
Related	1MVC 3OAP 4K6I
Descriptor	Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2 peptide, (2E,4E,6Z,8E)-8-(3,4-dihydronaphthalen-1(2H)-ylidene)-3,7-dimethylocta-2,4,6-trienoic acid, ... (4 entities in total)
Functional Keywords	ligand binding domain, cancer, 9-cis-uab30, transcription
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P19793 Q15596
Total number of polymer chains	2
Total formula weight	27771.27
Authors	Xia, G.,Smith, C.D.,Muccio, D.D. (deposition date: 2013-04-12, release date: 2013-11-13, Last modification date: 2023-09-20)
Primary citation	Boerma, L.J.,Xia, G.,Qui, C.,Cox, B.D.,Chalmers, M.J.,Smith, C.D.,Lobo-Ruppert, S.,Griffin, P.R.,Muccio, D.D.,Renfrow, M.B. Defining the Communication between Agonist and Coactivator Binding in the Retinoid X Receptor alpha Ligand Binding Domain. J.Biol.Chem., 289:814-826, 2014 Cited by PubMed: 24187139 DOI: 10.1074/jbc.M113.476861 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation