4JYH

Crystal structure of RARbeta LBD in complex with selective agonist BMS948 [4-{[(8-phenylnaphthalen-2-yl)carbonyl]amino}benzoic acid]

Summary for 4JYH

• Entry DOI: 10.2210/pdb4jyh/pdb
• Related: 1XAP 4DM6 4DM8 4JYG 4JYI
• Descriptor: Retinoic acid receptor beta, Nuclear receptor coactivator 1, 4-{[(8-phenylnaphthalen-2-yl)carbonyl]amino}benzoic acid, ... (5 entities in total)
• Functional Keywords: ligand binding domain, nuclear hormone receptor, transcription-agonist complex, transcription/agonist
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform Beta-1: Nucleus. Isoform Beta-2: Nucleus. Isoform Beta-4: Cytoplasm: P10826; Nucleus : Q15788
• Total number of polymer chains: 4
• Total formula weight: 64501.65

Authors

Nadendla, E.K.,Teyssier, C.,Germain, P.,Delfosse, V.,Bourguet, W. (deposition date: 2013-03-29, release date: 2014-03-19, Last modification date: 2024-02-28)

• Primary citation: Nadendla, E.,Teyssier, C.,Delfosse, V.,Vivat, V.,Krishnasamy, G.,Gronemeyer, H.,Bourguet, W.,Germain, P.; An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor beta (RAR beta , NR1B2) Selective Agonist.; Plos One, 10:e0123195-e0123195, 2015; PubMed: 25933005; DOI: 10.1371/journal.pone.0123195

Experimental method

X-RAY DIFFRACTION (2.6 Å)