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4JXF

Crystal Structure of PLK4 Kinase with an inhibitor: 400631 ((1R,2S)-2-{3-[(E)-2-{4-[(DIMETHYLAMINO)METHYL]PHENYL}ETHENYL]-2H-INDAZOL-6-YL}-5'-METHOXYSPIRO[CYCLOPROPANE-1,3'-INDOL]-2'(1'H)-ONE)

Summary for 4JXF
Entry DOI10.2210/pdb4jxf/pdb
DescriptorSerine/threonine-protein kinase PLK4, (1R,2S)-2-{3-[(E)-2-{4-[(dimethylamino)methyl]phenyl}ethenyl]-2H-indazol-6-yl}-5'-methoxyspiro[cyclopropane-1,3'-indol]-2'(1'H)-one, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsserine/threonine kinase, polo-like kinase 4, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole: O00444
Total number of polymer chains1
Total formula weight31105.07
Authors
Qiu, W.,Plotnikova, O.,Feher, M.,Awrey, D.E.,Chirgadze, N.Y. (deposition date: 2013-03-28, release date: 2014-04-02, Last modification date: 2023-09-20)
Primary citationQiu, W.,Plotnikova, O.,Feher, M.,Awrey, D.E.,Chirgadze, N.Y.
Crystal Structure of PLK4 Kinase with an inhibitor: 400631
To be Published,
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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