4JVB

Crystal structure of PDE6D in complex with the inhibitor rac-2

Summary for 4JVB

Entry DOI	10.2210/pdb4jvb/pdb
Related	4JV6 4JV8 4JVF
Descriptor	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, 1-benzyl-2-(4-{[(2R)-2-(2-phenyl-1H-benzimidazol-1-yl)pent-4-en-1-yl]oxy}phenyl)-1H-benzimidazole (3 entities in total)
Functional Keywords	immunoglobulin-like beta-sandwich, gdi-like solubilizing factor, prenyl binding, protein binding-inhibitor complex, protein binding/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	18145.81
Authors	Gunther, Z.,Papke, B.,Ismail, S.,Vartak, N.,Chandra, A.,Hoffmann, M.,Hahn, S.,Triola, G.,Wittinghofer, A.,Bastiaens, P.,Waldmann, H. (deposition date: 2013-03-25, release date: 2013-05-22, Last modification date: 2023-09-20)
Primary citation	Zimmermann, G.,Papke, B.,Ismail, S.,Vartak, N.,Chandra, A.,Hoffmann, M.,Hahn, S.A.,Triola, G.,Wittinghofer, A.,Bastiaens, P.I.,Waldmann, H. Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling Nature, 497:638-642, 2013 Cited by PubMed: 23698361 DOI: 10.1038/nature12205 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation