4JV4

Crystal Structure of RIalpha(91-379) bound to HE33, a N6 di-propyl substituted cAMP analog

Summary for 4JV4

Entry DOI	10.2210/pdb4jv4/pdb
Related	1NE4 1NE6 1RGS
Descriptor	cAMP-dependent protein kinase type I-alpha regulatory subunit, (2R,4aR,6R,7R,7aS)-6-[6-(dipropylamino)-9H-purin-9-yl]tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide (2 entities in total)
Functional Keywords	camp-dependent protein kinase, cyclic nucleotide analogs, isoform selectivity, fluorescence anisotropy, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Bos taurus (bovine,cow,domestic cattle,domestic cow)
Cellular location	Cell membrane (By similarity): P00514
Total number of polymer chains	1
Total formula weight	33320.58
Authors	Brown, S.H.J.,Cheng, C.Y.,Saldanha, A.S.,Wu, J.,Cottam, H.,Sankaran, B.,Taylor, S.S. (deposition date: 2013-03-25, release date: 2013-09-18, Last modification date: 2023-09-20)
Primary citation	Brown, S.H.,Cheng, C.Y.,Saldanha, S.A.,Wu, J.,Cottam, H.B.,Sankaran, B.,Taylor, S.S. Implementing Fluorescence Anisotropy Screening and Crystallographic Analysis to Define PKA Isoform-Selective Activation by cAMP Analogs. Acs Chem.Biol., 8:2164-2172, 2013 Cited by PubMed: 23978166 DOI: 10.1021/cb400247t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.952 Å)

Structure validation