4JS2

Crystal structure of human Beta-galactoside alpha-2,6-sialyltransferase 1 in complex with CMP

Summary for 4JS2

• Entry DOI: 10.2210/pdb4js2/pdb
• Related: 4JS1
• Descriptor: Beta-galactoside alpha-2,6-sialyltransferase 1, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CYTIDINE-5'-MONOPHOSPHATE, ... (4 entities in total)
• Functional Keywords: rossmann, gt-a, sialyltransferase, glycoprotein, sialylation, endoplasmatic reticulum, golgi, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 38932.73

Authors

Kuhn, B.,Benz, J.,Greif, M.,Engel, A.M.,Sobek, H.,Rudolph, M.G. (deposition date: 2013-03-22, release date: 2013-07-31, Last modification date: 2023-11-08)

• Primary citation: Kuhn, B.,Benz, J.,Greif, M.,Engel, A.M.,Sobek, H.,Rudolph, M.G.; The structure of human alpha-2,6-sialyltransferase reveals the binding mode of complex glycans.; Acta Crystallogr.,Sect.D, 69:1826-1838, 2013; PubMed: 23999306; DOI: 10.1107/S0907444913015412

Experimental method

X-RAY DIFFRACTION (2.3 Å)