4JR2
Human procaspase-7/caspase-7 heterodimer bound to Ac-DEVD-CMK
Summary for 4JR2
| Entry DOI | 10.2210/pdb4jr2/pdb |
| Related | 4JQY 4JQZ 4JR0 4JR1 |
| Related PRD ID | PRD_000238 |
| Descriptor | Procaspase-7, Ac-DEVD-CMK, CHLORIDE ION, ... (4 entities in total) |
| Functional Keywords | protease, proenzyme, protein-peptide complex, irreversible inhibitor, activity based probe, caspase, apoptosis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P55210 |
| Total number of polymer chains | 4 |
| Total formula weight | 57771.13 |
| Authors | Thomsen, N.D.,Wells, J.A. (deposition date: 2013-03-20, release date: 2013-05-08, Last modification date: 2023-09-20) |
| Primary citation | Thomsen, N.D.,Koerber, J.T.,Wells, J.A. Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation. Proc.Natl.Acad.Sci.USA, 110:8477-8482, 2013 Cited by PubMed: 23650375DOI: 10.1073/pnas.1306759110 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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