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4JQ8

Crystal structure of EGFR kinase domain in complex with compound 4b

Summary for 4JQ8
Entry DOI10.2210/pdb4jq8/pdb
Related4JQ7 4JR3 4JRV
DescriptorEpidermal growth factor receptor, N-[3-(4-{[(1S)-2-hydroxy-1-phenylethyl]amino}-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl]-N~3~,N~3~-dimethyl-beta-alaninamide (3 entities in total)
Functional Keywordstransferase, tyrosine kinase domain, atp-binding domain, autophosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains1
Total formula weight37922.86
Authors
Peng, Y.H.,Wu, J.S. (deposition date: 2013-03-20, release date: 2013-06-19, Last modification date: 2023-11-08)
Primary citationPeng, Y.H.,Shiao, H.Y.,Tu, C.H.,Liu, P.M.,Hsu, J.T.,Amancha, P.K.,Wu, J.S.,Coumar, M.S.,Chen, C.H.,Wang, S.Y.,Lin, W.H.,Sun, H.Y.,Chao, Y.S.,Lyu, P.C.,Hsieh, H.P.,Wu, S.Y.
Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors
J.Med.Chem., 56:3889-3903, 2013
Cited by
PubMed: 23611691
DOI: 10.1021/jm400072p
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.83 Å)
Structure validation

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