4JPG

2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as Novel PKM2 Activators

Summary for 4JPG

• Entry DOI: 10.2210/pdb4jpg/pdb
• Descriptor: Pyruvate kinase isozymes M1/M2, 1,6-di-O-phosphono-beta-D-fructofuranose, 2-(1H-benzimidazol-1-ylmethyl)-4H-pyrido[1,2-a]pyrimidin-4-one, ... (4 entities in total)
• Functional Keywords: pyruvate kinase, transferase-transferase activator complex, transferase/transferase activator
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 245725.36

Authors

Greasley, S.E.,Hickey, M.,Phonephaly, H.,Cronin, C. (deposition date: 2013-03-19, release date: 2013-05-22, Last modification date: 2024-02-28)

• Primary citation: Guo, C.,Linton, A.,Jalaie, M.,Kephart, S.,Ornelas, M.,Pairish, M.,Greasley, S.,Richardson, P.,Maegley, K.,Hickey, M.,Li, J.,Wu, X.,Ji, X.,Xie, Z.; Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators.; Bioorg.Med.Chem.Lett., 23:3358-3363, 2013; PubMed: 23622982; DOI: 10.1016/j.bmcl.2013.03.090

Experimental method

X-RAY DIFFRACTION (2.33 Å)