4JNM
Discovery of Potent and Efficacious Urea-containing Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors with Reduced CYP2C9 Inhibition Properties
Summary for 4JNM
Entry DOI | 10.2210/pdb4jnm/pdb |
Descriptor | Nicotinamide phosphoribosyltransferase, 1-[(6-aminopyridin-3-yl)methyl]-3-[4-(phenylsulfonyl)phenyl]urea, PHOSPHATE ION, ... (5 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): P43490 |
Total number of polymer chains | 2 |
Total formula weight | 115650.19 |
Authors | Gunzner-Toste, J.,Zhao, G.,Bauer, P.,Baumeister, T.,Buckmelter, A.J.,Caligiuri, M.,Clodfelter, K.H.,Fu, B.,Han, B.,Ho, Y.,Kley, N.,Liederer, B.,Lin, J.,Mukadam, S.,O'Brien, T.,Reynolds, D.J.,Sharma, G.,Skelton, N.,Smith, C.C.,Oh, A.,Wang, W.,Wang, Z.,Xiao, Y.,Yuen, P.,Zak, M.,Zhang, L.,Zheng, X.,Bair, K.W.,Dragovich, P.S. (deposition date: 2013-03-15, release date: 2013-05-29, Last modification date: 2024-02-28) |
Primary citation | Gunzner-Toste, J.,Zhao, G.,Bauer, P.,Baumeister, T.,Buckmelter, A.J.,Caligiuri, M.,Clodfelter, K.H.,Fu, B.,Han, B.,Ho, Y.C.,Kley, N.,Liang, X.,Liederer, B.M.,Lin, J.,Mukadam, S.,O'Brien, T.,Oh, A.,Reynolds, D.J.,Sharma, G.,Skelton, N.,Smith, C.C.,Sodhi, J.,Wang, W.,Wang, Z.,Xiao, Y.,Yuen, P.W.,Zak, M.,Zhang, L.,Zheng, X.,Bair, K.W.,Dragovich, P.S. Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties. Bioorg.Med.Chem.Lett., 23:3531-3538, 2013 Cited by PubMed: 23668988DOI: 10.1016/j.bmcl.2013.04.040 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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