4JN2

An Antidote for Dabigatran

Summary for 4JN2

• Entry DOI: 10.2210/pdb4jn2/pdb
• Related: 4JN1
• Descriptor: anti dabigatran Fab, N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine, GLYCEROL, ... (5 entities in total)
• Functional Keywords: igg fragment binding dabigatran, dabigatran, immune system-inhibitor complex, immune system/inhibitor
• Biological source: Mus musculus (mouse); More
• Total number of polymer chains: 4
• Total formula weight: 97352.88

Authors

Schiele, F.,Nar, H. (deposition date: 2013-03-14, release date: 2013-03-27, Last modification date: 2015-03-11)

• Primary citation: Schiele, F.,van Ryn, J.,Canada, K.,Newsome, C.,Sepulveda, E.,Park, J.,Nar, H.,Litzenburger, T.; A specific antidote for dabigatran: functional and structural characterization.; Blood, 121:3554-3562, 2013; PubMed: 23476049; DOI: 10.1182/blood-2012-11-468207

Experimental method

X-RAY DIFFRACTION (1.71 Å)