4JFJ

Increasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with compound (1S,6R)-10-(1,3-benzothiazol-6-ylsulfonyl)-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one

Summary for 4JFJ

Entry DOI	10.2210/pdb4jfj/pdb
Related	4JFI 4JFK 4JFL 4JFM
Descriptor	Peptidyl-prolyl cis-trans isomerase FKBP5, (1S,6R)-10-(1,3-benzothiazol-6-ylsulfonyl)-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one (3 entities in total)
Functional Keywords	fk-506 binding domain, hsp90 cochaperone, immunophiline, peptidyl-prolyl isomerase, isomerase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q13451
Total number of polymer chains	1
Total formula weight	14557.72
Authors	Wang, Y.,Kirschner, A.,Fabian, A.,Gopalakrishnan, R.,Kress, C.,Hoogeland, B.,Koch, U.,Kozany, C.,Bracher, A.,Hausch, F. (deposition date: 2013-02-28, release date: 2013-08-28, Last modification date: 2024-02-28)
Primary citation	Wang, Y.,Kirschner, A.,Fabian, A.K.,Gopalakrishnan, R.,Kress, C.,Hoogeland, B.,Koch, U.,Kozany, C.,Bracher, A.,Hausch, F. Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control. J.Med.Chem., 56:3922-3935, 2013 Cited by PubMed: 23647266 DOI: 10.1021/jm400087k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.08 Å)

Structure validation