4JEF
Crystal structure of human thymidylate synthase Y202A in inactive conformation.
Summary for 4JEF
| Entry DOI | 10.2210/pdb4jef/pdb |
| Related | 3EGY 3EHI 4E28 4FGT |
| Descriptor | Thymidylate synthase, SULFATE ION (3 entities in total) |
| Functional Keywords | inactive form of human thymidylate synthase, hot spot residue, transferase |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus : P04818 |
| Total number of polymer chains | 1 |
| Total formula weight | 33213.97 |
| Authors | Tochowicz, A.,Stroud, R.M.,Wade, R.C. (deposition date: 2013-02-26, release date: 2014-08-20, Last modification date: 2015-05-06) |
| Primary citation | Salo-Ahen, O.M.,Tochowicz, A.,Pozzi, C.,Cardinale, D.,Ferrari, S.,Boum, Y.,Mangani, S.,Stroud, R.M.,Saxena, P.,Myllykallio, H.,Costi, M.P.,Ponterini, G.,Wade, R.C. Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase. J.Med.Chem., 58:3572-3581, 2015 Cited by PubMed: 25798950DOI: 10.1021/acs.jmedchem.5b00137 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.311 Å) |
Structure validation
Download full validation report
