4J21

Tankyrase 2 in complex with 7-(4-amino-2-chlorophenyl)-4-methylquinolin-2(1H)-one

Summary for 4J21

Entry DOI	10.2210/pdb4j21/pdb
Related	3W51 4IUE 4J1Z 4J22
Descriptor	Tankyrase-2, ZINC ION, SULFATE ION, ... (5 entities in total)
Functional Keywords	ribosylation, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q9H2K2
Total number of polymer chains	1
Total formula weight	24535.47
Authors	Jansson, A.E.,Larsson, E.A.,Nordlund, P.L. (deposition date: 2013-02-04, release date: 2013-06-26, Last modification date: 2023-11-08)
Primary citation	Larsson, E.A.,Jansson, A.E.,Ng, F.M.,Then, S.W.,Panicker, R.,Liu, B.,Sangthongpitag, K.,Pendharkar, V.,Tai, S.J.,Hill, J.,Dan, C.,Ho, S.Y.,Cheong, W.W.,Poulsen, A.,Blanchard, S.,Lin, G.R.,Alam, J.,Keller, T.H.,Nordlund, P. Fragment-based ligand design of novel potent inhibitors of tankyrases. J.Med.Chem., 56:4497-4508, 2013 Cited by PubMed: 23672613 DOI: 10.1021/jm400211f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.93 Å)

Structure validation