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4IXC

Crystal structure of Human Glucokinase in complex with a small molecule activator.

Summary for 4IXC
Entry DOI10.2210/pdb4ixc/pdb
DescriptorGlucokinase isoform 3, SODIUM ION, alpha-D-glucopyranose, ... (5 entities in total)
Functional Keywordsallosteric regulation, binding sites, catalytic domain, diabetes mellitus, type 2, enzyme activators, glucokinase, hexokinase, humans, models, molecular, mutation, protein conformation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight51478.73
Authors
Ogg, D.J.,Hargreaves, D.,Gerhardt, S. (deposition date: 2013-01-25, release date: 2013-04-24, Last modification date: 2020-07-29)
Primary citationWaring, M.J.,Bennett, S.N.L.,Boyd, S.,Campbell, L.,Davies, R.D.M.,Gerhardt, S.,Hargreaves, D.,G Martin, N.,Robb, G.R.,Wilkinson, G.
Matched triplicate design sets in the optimisation of glucokinase activators maximising medicinal chemistry information content
To be Published,
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

217705

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