4IW6

Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Constrained WAY-derivative, 7b

Summary for 4IW6

Entry DOI	10.2210/pdb4iw6/pdb
Related	4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW8 4IWC 4IWF
Descriptor	Estrogen receptor, Nuclear receptor coactivator 2, 4-[2-(but-3-en-1-yl)-7-(trifluoromethyl)-2H-indazol-3-yl]benzene-1,3-diol, ... (4 entities in total)
Functional Keywords	nuclear hormone receptor, transcription factor, ligand-binding, nucleus, transcription
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	59628.16
Authors	Nwachukwu, J.C.,Srinivasan, S.,Parent, A.A.,Cavett, V.,Nowak, J.,Hughes, T.S.,Kojetin, D.J.,Katzenellenbogen, J.A.,Nettles, K.W. (deposition date: 2013-01-23, release date: 2013-03-27, Last modification date: 2023-09-20)
Primary citation	Srinivasan, S.,Nwachukwu, J.C.,Parent, A.A.,Cavett, V.,Nowak, J.,Hughes, T.S.,Kojetin, D.J.,Katzenellenbogen, J.A.,Nettles, K.W. Ligand binding dynamics rewire cellular signaling via Estrogen Receptor-alpha Nat.Chem.Biol., 9:326-332, 2013 Cited by PubMed: 23524984 DOI: 10.1038/nchembio.1214 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation