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4IVY

Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Dynamic WAY-derivative, 7a

Summary for 4IVY
Entry DOI10.2210/pdb4ivy/pdb
Related4IU7 4IUI 4IV2 4IV4 4IVW 4IW6 4IW8 4IWC 4IWF
DescriptorEstrogen receptor, Nuclear receptor coactivator 2, 4-[1-(but-3-en-1-yl)-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol, ... (4 entities in total)
Functional Keywordsnuclear hormone receptor, transcription factor, ligand-binding, nucleus, transcription
Biological sourceHomo sapiens (human)
More
Total number of polymer chains4
Total formula weight59628.16
Authors
Nwachukwu, J.C.,Srinivasan, S.,Parent, A.A.,Cavett, V.,Nowak, J.,Hughes, T.S.,Kojetin, D.J.,Katzenellenbogen, J.A.,Nettles, K.W. (deposition date: 2013-01-23, release date: 2013-03-27, Last modification date: 2023-09-20)
Primary citationSrinivasan, S.,Nwachukwu, J.C.,Parent, A.A.,Cavett, V.,Nowak, J.,Hughes, T.S.,Kojetin, D.J.,Katzenellenbogen, J.A.,Nettles, K.W.
Ligand binding dynamics rewire cellular signaling via Estrogen Receptor-alpha
Nat.Chem.Biol., 9:326-332, 2013
Cited by
PubMed: 23524984
DOI: 10.1038/nchembio.1214
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

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