4IUM

Equine arteritis virus papain-like protease 2 (PLP2) covalently bound to ubiquitin

Summary for 4IUM

• Entry DOI: 10.2210/pdb4ium/pdb
• Descriptor: papain-like protease 2, Ubiquitin, ZINC ION, ... (5 entities in total)
• Functional Keywords: viral ovarian tumor domain (otu) protease, deubiquitinase, hydrolase-protein binding complex, hydrolase/protein binding
• Biological source: Equine arteritis virus (EAV); More
• Cellular location: Nsp1 papain-like cysteine proteinase: Host nucleus. Nsp2 cysteine proteinase: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 5-6-7: Host membrane; Multi-pass membrane protein (Potential). 3C-like serine proteinase: Host cytoplasm (Potential). RNA-directed RNA polymerase: Host cytoplasm, host perinuclear region (Potential). Helicase: Host cytoplasm, host perinuclear region (Potential): P19811; Ubiquitin: Cytoplasm (By similarity): P0CG48
• Total number of polymer chains: 2
• Total formula weight: 24044.80

Authors

Bailey-Elkin, B.A.,James, T.W.,Mark, B.L. (deposition date: 2013-01-21, release date: 2013-02-13, Last modification date: 2013-03-20)

• Primary citation: van Kasteren, P.B.,Bailey-Elkin, B.A.,James, T.W.,Ninaber, D.K.,Beugeling, C.,Khajehpour, M.,Snijder, E.J.,Mark, B.L.,Kikkert, M.; Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells.; Proc.Natl.Acad.Sci.USA, 110:E838-E847, 2013; PubMed: 23401522; DOI: 10.1073/pnas.1218464110

Experimental method

X-RAY DIFFRACTION (1.45 Å)