4ITI

Crystal structure of RIP1 kinase in complex with necrostatin-3 analog

Summary for 4ITI

• Entry DOI: 10.2210/pdb4iti/pdb
• Related: 4ITH 4ITJ
• Descriptor: Receptor-interacting serine/threonine-protein kinase 1, 1-{(3S,3aS)-3-[3-fluoro-4-(trifluoromethoxy)phenyl]-8-methoxy-3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl}-2-hydroxyethanone (2 entities in total)
• Functional Keywords: alpha/beta, rip1 kinase, necroptosis, necrostatins, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q13546
• Total number of polymer chains: 2
• Total formula weight: 67814.20

Authors

Xie, T.,Peng, W.,Liu, Y.,Yan, C.,Shi, Y. (deposition date: 2013-01-18, release date: 2013-03-13, Last modification date: 2023-09-20)

• Primary citation: Xie, T.,Peng, W.,Liu, Y.,Yan, C.,Maki, J.,Degterev, A.,Yuan, J.,Shi, Y.; Structural Basis of RIP1 Inhibition by Necrostatins.; Structure, 21:493-499, 2013; PubMed: 23473668; DOI: 10.1016/j.str.2013.01.016

Experimental method

X-RAY DIFFRACTION (2.86 Å)