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4ISG

Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-[4-(methylsulfonyl)-2-oxopiperazin-1-yl]-N-(1,3-thiazol-2-yl)propanamide

Summary for 4ISG
Entry DOI10.2210/pdb4isg/pdb
Related4ISE 4ISF
DescriptorGlucokinase, alpha-D-glucopyranose, (2S)-3-cyclohexyl-2-[4-(methylsulfonyl)-2-oxopiperazin-1-yl]-N-(1,3-thiazol-2-yl)propanamide, ... (5 entities in total)
Functional Keywordstransferase/activator activity, glucose conversion to g6p, phosphorylation, transferase-transferase activator complex, transferase/transferase activator
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight52114.13
Authors
Hosfield, D.,Skene, R.J. (deposition date: 2013-01-16, release date: 2013-03-20, Last modification date: 2024-02-28)
Primary citationCheruvallath, Z.S.,Gwaltney, S.L.,Sabat, M.,Tang, M.,Feng, J.,Wang, H.,Miura, J.,Guntupalli, P.,Jennings, A.,Hosfield, D.,Lee, B.,Wu, Y.
Design, synthesis and SAR of novel glucokinase activators.
Bioorg.Med.Chem.Lett., 23:2166-2171, 2013
Cited by
PubMed: 23434031
DOI: 10.1016/j.bmcl.2013.01.093
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.645 Å)
Structure validation

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