4ISE

Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-N-(1,3-thiazol-2-yl)propanamide

Summary for 4ISE

Entry DOI	10.2210/pdb4ise/pdb
Related	4ISF 4ISG
Descriptor	Glucokinase, alpha-D-glucopyranose, (2S)-3-cyclohexyl-2-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-N-(1,3-thiazol-2-yl)propanamide, ... (5 entities in total)
Functional Keywords	transferase/activator activity, glucose conversion to g6p, phosphorylation, transferase-transferase activator complex, transferase/transferase activator
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	52100.06
Authors	Hosfield, D.,Skene, R.J. (deposition date: 2013-01-16, release date: 2013-03-20, Last modification date: 2024-02-28)
Primary citation	Cheruvallath, Z.S.,Gwaltney, S.L.,Sabat, M.,Tang, M.,Feng, J.,Wang, H.,Miura, J.,Guntupalli, P.,Jennings, A.,Hosfield, D.,Lee, B.,Wu, Y. Design, synthesis and SAR of novel glucokinase activators. Bioorg.Med.Chem.Lett., 23:2166-2171, 2013 Cited by PubMed: 23434031 DOI: 10.1016/j.bmcl.2013.01.093 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation