4IR6

Crystal Structure of the bromodomain of human BAZ2B in complex with 1-{1-[2-(METHYLSULFONYL)PHENYL]-7-PHENOXYINDOLIZIN-3-YL}ETHANONE (GSK2838097A)

Summary for 4IR6

• Entry DOI: 10.2210/pdb4ir6/pdb
• Related: 4IR3 4IR4 4IR5 4RVR
• Descriptor: Bromodomain adjacent to zinc finger domain protein 2B, 1,2-ETHANEDIOL, 1-{1-[2-(methylsulfonyl)phenyl]-7-phenoxyindolizin-3-yl}ethanone, ... (4 entities in total)
• Functional Keywords: sgc, structural genomics consortium, transcription, bromodomain, acetylated lysine binding protein, kiaa1476, walp4
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : Q9UIF8
• Total number of polymer chains: 1
• Total formula weight: 14396.53

Authors

Chaikuad, A.,Felletar, I.,Chung, C.W.,Drewry, D.,Chen, P.,Filippakopoulos, P.,Fedorov, O.,Krojer, T.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2013-01-14, release date: 2013-01-23, Last modification date: 2023-09-20)

• Primary citation: Chen, P.,Chaikuad, A.,Bamborough, P.,Bantscheff, M.,Bountra, C.,Chung, C.W.,Fedorov, O.,Grandi, P.,Jung, D.,Lesniak, R.,Lindon, M.,Muller, S.,Philpott, M.,Prinjha, R.,Rogers, C.,Selenski, C.,Tallant, C.,Werner, T.,Willson, T.M.,Knapp, S.,Drewry, D.H.; Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.; J.Med.Chem., 59:1410-1424, 2016; PubMed: 25799074; DOI: 10.1021/acs.jmedchem.5b00209

Experimental method

X-RAY DIFFRACTION (1.8 Å)