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4IQX

Mutant P44S P169S M296I of Foot-and-mouth disease Virus RNA-dependent RNA polymerase

Summary for 4IQX
Entry DOI10.2210/pdb4iqx/pdb
Related3NKY 3NL0 3NMA
Descriptor3D polymerase, RNA (5'-R(*AP*UP*GP*GP*GP*CP*C)-3'), RNA (5'-R(*GP*GP*CP*CP*C)-3'), ... (4 entities in total)
Functional Keywordsclose right hand conformation, rna-dependent rna polymerase, 3d polymerase, transferase-dna complex, transferase/dna
Biological sourceFoot-and-mouth disease virus - type C
More
Cellular locationPicornain 3C: Host cytoplasm (By similarity): Q9QCE4
Total number of polymer chains3
Total formula weight57878.65
Authors
Ferrer-Orta, C.,Verdaguer, N.,Agudo, R.,Perez-Luque, R. (deposition date: 2013-01-14, release date: 2013-02-06, Last modification date: 2024-02-28)
Primary citationAgudo, R.,Ferrer-Orta, C.,Arias, A.,de la Higuera, I.,Perales, C.,Perez-Luque, R.,Verdaguer, N.,Domingo, E.
A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape.
Plos Pathog., 6:e1001072-e1001072, 2010
Cited by
PubMed: 20865120
DOI: 10.1371/journal.ppat.1001072
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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