4IKP

Crystal structure of coactivator-associated arginine methyltransferase 1 with methylenesinefungin

Summary for 4IKP

• Entry DOI: 10.2210/pdb4ikp/pdb
• Descriptor: Histone-arginine methyltransferase CARM1, (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid, GLYCEROL, ... (5 entities in total)
• Functional Keywords: structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q86X55
• Total number of polymer chains: 4
• Total formula weight: 157026.72

Authors

Dong, A.,Dombrovski, L.,He, H.,Ibanez, G.,Wernimont, A.,Zheng, W.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Min, J.,Luo, M.,Wu, H.,Structural Genomics Consortium (SGC) (deposition date: 2012-12-27, release date: 2013-02-13, Last modification date: 2023-09-20)

• Primary citation: Cai, X.C.,Zhang, T.,Kim, E.J.,Jiang, M.,Wang, K.,Wang, J.,Chen, S.,Zhang, N.,Wu, H.,Li, F.,Dela Sena, C.C.,Zeng, H.,Vivcharuk, V.,Niu, X.,Zheng, W.,Lee, J.P.,Chen, Y.,Barsyte, D.,Szewczyk, M.,Hajian, T.,Ibanez, G.,Dong, A.,Dombrovski, L.,Zhang, Z.,Deng, H.,Min, J.,Arrowsmith, C.H.,Mazutis, L.,Shi, L.,Vedadi, M.,Brown, P.J.,Xiang, J.,Qin, L.X.,Xu, W.,Luo, M.; A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion.; Elife, 8:-, 2019; PubMed: 31657716; DOI: 10.7554/eLife.47110

Experimental method

X-RAY DIFFRACTION (2 Å)