4IGK

Structure of human BRCA1 BRCT in complex with ATRIP peptide

Summary for 4IGK

• Entry DOI: 10.2210/pdb4igk/pdb
• Related: 4IFI
• Descriptor: Breast cancer type 1 susceptibility protein, ATRIP peptide, GLYCEROL, ... (4 entities in total)
• Functional Keywords: cell cycle, disease mutation, dna damage, dna repair, fatty acid biosynthesis, ligase, lipid synthesis, metal-binding, nucleus, phosphoprotein, tumor suppressor, ubl conjugation pathway, zinc-finger, brct domain, dna damage response, phospho peptide interactions, dna-binding, phospho peptide binding, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus. Isoform 3: Cytoplasm. Isoform 5: Cytoplasm: P38398; Nucleus: Q8WXE1
• Total number of polymer chains: 4
• Total formula weight: 51008.37

Authors

Liu, X.,Ladias, J.A.A. (deposition date: 2012-12-17, release date: 2013-10-30, Last modification date: 2023-09-20)

• Primary citation: Liu, X.,Ladias, J.A.; Structural Basis for the BRCA1 BRCT Interaction with the Proteins ATRIP and BAAT1.; Biochemistry, 52:7618-7627, 2013; PubMed: 24073851; DOI: 10.1021/bi400714v

Experimental method

X-RAY DIFFRACTION (1.75 Å)