Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4IDV

Crystal Structure of NIK with compound 4-{3-[2-amino-5-(2-methoxyethoxy)pyrimidin-4-yl]-1H-indol-5-yl}-2-methylbut-3-yn-2-ol (13V)

Summary for 4IDV
Entry DOI10.2210/pdb4idv/pdb
Related4IDT
DescriptorMitogen-activated protein kinase kinase kinase 14, 4-{3-[2-amino-5-(2-methoxyethoxy)pyrimidin-4-yl]-1H-indol-5-yl}-2-methylbut-3-yn-2-ol (3 entities in total)
Functional Keywordsnik, nuclear factor (nf)-kb, p100 processing, 2-aminopyrimidine, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: Q99558
Total number of polymer chains4
Total formula weight158048.47
Authors
Liu, J.,Sudom, A.,Wang, Z. (deposition date: 2012-12-13, release date: 2013-04-17, Last modification date: 2024-02-28)
Primary citationLi, K.,McGee, L.R.,Fisher, B.,Sudom, A.,Liu, J.,Rubenstein, S.M.,Anwer, M.K.,Cushing, T.D.,Shin, Y.,Ayres, M.,Lee, F.,Eksterowicz, J.,Faulder, P.,Waszkowycz, B.,Plotnikova, O.,Farrelly, E.,Xiao, S.H.,Chen, G.,Wang, Z.
Inhibiting NF-KB-inducing kinase (NIK): Discovery, structure-based design, synthesis, structure activity relationship, and co-crystal structures
Bioorg.Med.Chem.Lett., 23:1238-1244, 2013
Cited by
PubMed: 23374866
DOI: 10.1016/j.bmcl.2013.01.012
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon