4IAR

Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with ergotamine (PSI Community Target)

4IAR の概要

• エントリーDOI: 10.2210/pdb4iar/pdb
• 関連するPDBエントリー: 4IAQ
• 分子名称: Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562, Ergotamine, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (4 entities in total)
• 機能のキーワード: ergotamine, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, signaling protein, electron transport, gpcr dock
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane ; Multi-pass membrane protein : P28222
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46210.88

構造登録者

Wang, C.,Jiang, Y.,Ma, J.,Wu, H.,Wacker, D.,Katritch, V.,Han, G.W.,Liu, W.,Huang, X.,Vardy, E.,McCorvy, J.D.,Gao, X.,Zhou, E.X.,Melcher, K.,Zhang, C.,Bai, F.,Yang, H.,Yang, L.,Jiang, H.,Roth, B.L.,Cherezov, V.,Stevens, R.C.,Xu, H.E.,GPCR Network (GPCR) (登録日: 2012-12-07, 公開日: 2013-03-13, 最終更新日: 2023-09-20)

• 主引用文献: Wang, C.,Jiang, Y.,Ma, J.,Wu, H.,Wacker, D.,Katritch, V.,Han, G.W.,Liu, W.,Huang, X.P.,Vardy, E.,McCorvy, J.D.,Gao, X.,Zhou, X.E.,Melcher, K.,Zhang, C.,Bai, F.,Yang, H.,Yang, L.,Jiang, H.,Roth, B.L.,Cherezov, V.,Stevens, R.C.,Xu, H.E.; Structural basis for molecular recognition at serotonin receptors.; Science, 340:610-614, 2013; PubMed: 23519210; DOI: 10.1126/science.1232807

実験手法

X-RAY DIFFRACTION (2.7 Å)