4IAH

Crystal Structure of BAY 60-2770 bound C139A H-NOX domain with S-nitrosylated conserved C122

Summary for 4IAH

• Entry DOI: 10.2210/pdb4iah/pdb
• Related: 2O09 2O0C 2O0G 3L6J 4IAE 4IAM
• Descriptor: Alr2278 protein, 4-({(4-carboxybutyl)[2-(5-fluoro-2-{[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]amino}methyl)benzoic acid, MALONATE ION, ... (4 entities in total)
• Functional Keywords: h-nox domain, soluble guanylyl cyclase, bay 60-2770, s-nitrosylation, conserved c122, heme binding, no binding, lyase
• Biological source: Nostoc sp.
• Total number of polymer chains: 2
• Total formula weight: 42226.96

Authors

Kumar, V.,van den Akker, F. (deposition date: 2012-12-06, release date: 2013-11-20, Last modification date: 2023-09-20)

• Primary citation: Kumar, V.,Martin, F.,Hahn, M.G.,Schaefer, M.,Stamler, J.S.,Stasch, J.P.,van den Akker, F.; Insights into BAY 60-2770 Activation and S-Nitrosylation-Dependent Desensitization of Soluble Guanylyl Cyclase via Crystal Structures of Homologous Nostoc H-NOX Domain Complexes.; Biochemistry, 52:3601-3608, 2013; PubMed: 23614626; DOI: 10.1021/bi301657w

Experimental method

X-RAY DIFFRACTION (2.8 Å)