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4IA9

Crystal structure of human WD REPEAT DOMAIN 5 in complex with 2-chloro-4-fluoro-3-methyl-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide

Summary for 4IA9
Entry DOI10.2210/pdb4ia9/pdb
DescriptorWD repeat-containing protein 5, 2-chloro-4-fluoro-3-methyl-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordswdr5, structural genomics consortium, wd repeat domain 5, transcription, sgc
Biological sourceHomo sapiens (human)
Cellular locationNucleus : P61964
Total number of polymer chains1
Total formula weight34820.86
Authors
Primary citationBolshan, Y.,Getlik, M.,Kuznetsova, E.,Wasney, G.A.,Hajian, T.,Poda, G.,Nguyen, K.T.,Wu, H.,Dombrovski, L.,Dong, A.,Senisterra, G.,Schapira, M.,Arrowsmith, C.H.,Brown, P.J.,Al-Awar, R.,Vedadi, M.,Smil, D.
Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction.
ACS Med Chem Lett, 4:353-357, 2013
Cited by
PubMed: 24900672
DOI: 10.1021/ml300467n
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.66 Å)
Structure validation

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