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4I9I

Crystal structure of tankyrase 1 with compound 4

Summary for 4I9I
Entry DOI10.2210/pdb4i9i/pdb
Related4DVI
DescriptorTankyrase-1, ZINC ION, N-(2-methoxyphenyl)-4-{[3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanoyl]amino}benzamide, ... (4 entities in total)
Functional Keywordstankyrase, parp, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: O95271
Total number of polymer chains4
Total formula weight102196.83
Authors
Huang, X. (deposition date: 2012-12-05, release date: 2013-02-06, Last modification date: 2013-05-22)
Primary citationBregman, H.,Gunaydin, H.,Gu, Y.,Schneider, S.,Wilson, C.,DiMauro, E.F.,Huang, X.
Discovery of a class of novel tankyrase inhibitors that bind to both the nicotinamide pocket and the induced pocket.
J.Med.Chem., 56:1341-1345, 2013
Cited by
PubMed: 23316926
DOI: 10.1021/jm301607v
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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