4I8X

Crystal structure of rabbit LDHA in complex with AP27460

Summary for 4I8X

Entry DOI	10.2210/pdb4i8x/pdb
Related	4I9H 4I9N 4I9U
Descriptor	L-lactate dehydrogenase A chain, 6-phenylpyridine-3-carboxylic acid (3 entities in total)
Functional Keywords	fragment, inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Oryctolagus cuniculus (rabbit)
Cellular location	Cytoplasm: P13491
Total number of polymer chains	8
Total formula weight	293444.64
Authors	Zhou, T.,Stephan, Z.G.,Kohlmann, A.,Li, F.,Commodore, L.,Greenfield, M.T.,Zhu, X.,Dalgarno, D.C. (deposition date: 2012-12-04, release date: 2013-01-23, Last modification date: 2023-09-20)
Primary citation	Kohlmann, A.,Zech, S.G.,Li, F.,Zhou, T.,Squillace, R.M.,Commodore, L.,Greenfield, M.T.,Lu, X.,Miller, D.P.,Huang, W.S.,Qi, J.,Thomas, R.M.,Wang, Y.,Zhang, S.,Dodd, R.,Liu, S.,Xu, R.,Xu, Y.,Miret, J.J.,Rivera, V.,Clackson, T.,Shakespeare, W.C.,Zhu, X.,Dalgarno, D.C. Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors. J.Med.Chem., 56:1023-1040, 2013 Cited by PubMed: 23302067 DOI: 10.1021/jm3014844 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.23 Å)

Structure validation