4I85

Crystal structure of transthyretin in complex with CHF5074 at neutral pH

Summary for 4I85

Entry DOI	10.2210/pdb4i85/pdb
Related	1DVT 1F41 1ROX 2G3X 3D2T 4I87 4I89
Descriptor	Transthyretin, 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid (3 entities in total)
Functional Keywords	amyloidosis, fibrillogenesis, amyloid fibrils, t3 or t4 hormone binding, plasma, transport protein-inhibitor complex, transport protein/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	28205.04
Authors	Zanotti, G.,Cendron, L.,Folli, C.,Florio, P.,Imbimbo, B.P.,Berni, R. (deposition date: 2012-12-03, release date: 2013-06-19, Last modification date: 2023-09-20)
Primary citation	Zanotti, G.,Cendron, L.,Folli, C.,Florio, P.,Imbimbo, B.P.,Berni, R. Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitors. Febs Lett., 587:2325-2331, 2013 Cited by PubMed: 23792159 DOI: 10.1016/j.febslet.2013.06.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.67 Å)

Structure validation