4I6F

Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain

Summary for 4I6F

• Entry DOI: 10.2210/pdb4i6f/pdb
• Related: 4I5M 4I5P 4I6B 4I6H
• Descriptor: Serine/threonine-protein kinase PLK2, (7R)-8-cyclopentyl-7-ethyl-5-methyl-2-(2-phenyl-1H-imidazol-1-yl)-7,8-dihydropteridin-6(5H)-one (3 entities in total)
• Functional Keywords: polo-like kinase-2 (plk-2), synuclein, parkinsons disease, kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole: Q9NYY3
• Total number of polymer chains: 1
• Total formula weight: 36234.68

Authors

Pan, H. (deposition date: 2012-11-29, release date: 2013-11-20, Last modification date: 2024-02-28)

• Primary citation: Aubele, D.L.,Hom, R.K.,Adler, M.,Galemmo, R.A.,Bowers, S.,Truong, A.P.,Pan, H.,Beroza, P.,Neitz, R.J.,Yao, N.,Lin, M.,Tonn, G.,Zhang, H.,Bova, M.P.,Ren, Z.,Tam, D.,Ruslim, L.,Baker, J.,Diep, L.,Fitzgerald, K.,Hoffman, J.,Motter, R.,Fauss, D.,Tanaka, P.,Dappen, M.,Jagodzinski, J.,Chan, W.,Konradi, A.W.,Latimer, L.,Zhu, Y.L.,Sham, H.L.,Anderson, J.P.,Bergeron, M.,Artis, D.R.; Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce alpha-synuclein phosphorylation in rat brain.; Chemmedchem, 8:1295-1313, 2013; PubMed: 23794260; DOI: 10.1002/cmdc.201300166

Experimental method

X-RAY DIFFRACTION (2.9 Å)