4I5L

Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation

Summary for 4I5L

• Entry DOI: 10.2210/pdb4i5l/pdb
• Related: 2IE3 2NPP 3P71 4I5J 4I5K 4I5N
• Related PRD ID: PRD_001031
• Descriptor: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta - Cell division control protein 6 homolog chimeric construct, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha, ... (9 entities in total)
• Functional Keywords: ef hand, phosphatase, cdc6 (substrate), hydrolase-toxin complex, hydrolase/toxin
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm : P30153 P67775; Nucleus : Q99741
• Total number of polymer chains: 8
• Total formula weight: 299714.82

Authors

Wlodarchak, N.,Satyshur, K.A.,Guo, F.,Xing, Y. (deposition date: 2012-11-28, release date: 2013-05-08, Last modification date: 2023-11-15)

• Primary citation: Wlodarchak, N.,Guo, F.,Satyshur, K.A.,Jiang, L.,Jeffrey, P.D.,Sun, T.,Stanevich, V.,Mumby, M.C.,Xing, Y.; Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation.; Cell Res., 23:931-946, 2013; PubMed: 23752926; DOI: 10.1038/cr.2013.77

Experimental method

X-RAY DIFFRACTION (2.43 Å)