4I2P

Crystal structure of HIV-1 reverse transcriptase in complex with rilpivirine (TMC278) based analogue

Summary for 4I2P

• Entry DOI: 10.2210/pdb4i2p/pdb
• Descriptor: Gag-Pol polyprotein, (2E)-3-[4-({6-[(4-methoxyphenyl)amino]-7H-purin-2-yl}amino)-3,5-dimethylphenyl]prop-2-enenitrile, ... (4 entities in total)
• Functional Keywords: p51/p66, hetero dimer, nnrti, nonnucleoside inhibitor, aids, hiv, dna recombination, rna-directed dna polymerase, dna polymerase, endonuclease, hydrolase, multifunctional enzyme, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Human immunodeficiency virus type 1 BH10 (HIV-1); More
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
• Total number of polymer chains: 2
• Total formula weight: 114440.18

Authors

Patel, D.,Bauman, J.D.,Das, K.,Arnold, E. (deposition date: 2012-11-22, release date: 2013-01-16, Last modification date: 2024-02-28)

• Primary citation: Johnson, B.C.,Pauly, G.T.,Rai, G.,Patel, D.,Bauman, J.D.,Baker, H.L.,Das, K.,Schneider, J.P.,Maloney, D.J.,Arnold, E.,Thomas, C.J.,Hughes, S.H.; A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants.; Retrovirology, 9:99-99, 2012; PubMed: 23217210; DOI: 10.1186/1742-4690-9-99

Experimental method

X-RAY DIFFRACTION (2.2964 Å)