4I21

Crystal structure of L858R + T790M EGFR kinase domain in complex with MIG6 peptide

Summary for 4I21

Entry DOI	10.2210/pdb4i21/pdb
Related	4I1Z 4I20 4I22 4I23 4I24
Descriptor	Epidermal growth factor receptor, ERBB receptor feedback inhibitor 1 (2 entities in total)
Functional Keywords	egfr kinase domain, phosphotransfer, mig6 peptide, atp binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 Cytoplasm : Q9UJM3
Total number of polymer chains	4
Total formula weight	88243.49
Authors	Gajiwala, K.S.,Feng, J.,Ferre, R.,Ryan, K.,Brodsky, O.,Stewart, A. (deposition date: 2012-11-21, release date: 2013-01-16, Last modification date: 2024-02-28)
Primary citation	Gajiwala, K.S.,Feng, J.,Ferre, R.,Ryan, K.,Brodsky, O.,Weinrich, S.,Kath, J.C.,Stewart, A. Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition. Structure, 21:209-219, 2013 Cited by PubMed: 23273428 DOI: 10.1016/j.str.2012.11.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.37 Å)

Structure validation