4HY2

Crystal structure of Plk1 Polo-box domain in complex with PL-42

Summary for 4HY2

Entry DOI	10.2210/pdb4hy2/pdb
Related	4HAB
Related PRD ID	PRD_000922
Descriptor	Serine/threonine-protein kinase PLK1, PL-42 (3 entities in total)
Functional Keywords	polo-box domain, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P53350
Total number of polymer chains	2
Total formula weight	27001.74
Authors	Lee, W.C.,Song, J.H.,Kim, H.Y. (deposition date: 2012-11-12, release date: 2013-04-03, Last modification date: 2017-11-15)
Primary citation	Murugan, R.N.,Park, J.E.,Lim, D.,Ahn, M.,Cheong, C.,Kwon, T.,Nam, K.Y.,Choi, S.H.,Kim, B.Y.,Yoon, D.Y.,Yaffe, M.B.,Yu, D.Y.,Lee, K.S.,Bang, J.K. Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1. Bioorg.Med.Chem., 21:2623-2634, 2013 Cited by PubMed: 23498919 DOI: 10.1016/j.bmc.2013.02.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation