4HY0
Crystal structure of XIAP BIR3 with T3256336
Summary for 4HY0
Entry DOI | 10.2210/pdb4hy0/pdb |
Related PRD ID | PRD_001138 |
Descriptor | E3 ubiquitin-protein ligase XIAP, ZINC ION, (3S,7R,8aR)-2-{(2S)-2-(4,4-difluorocyclohexyl)-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(4R)-3,4-dihydro-2H-chromen-4-yl]-7-ethoxyoctahydropyrrolo[1,2-a]pyrazine-3-carboxamide, ... (4 entities in total) |
Functional Keywords | bir3, baculoviral iap repeat-containing protein 4, apoptotic suppressor. inhibitor of caspase-3, -7 and -9., interacts with smac and with prss25, xiap, birc4, x-linked inhibitor of apoptosis, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P98170 |
Total number of polymer chains | 8 |
Total formula weight | 119423.14 |
Authors | Snell, G.S.,Dougan, D.R. (deposition date: 2012-11-12, release date: 2013-01-30, Last modification date: 2024-02-28) |
Primary citation | Hashimoto, K.,Saito, B.,Miyamoto, N.,Oguro, Y.,Tomita, D.,Shiokawa, Z.,Asano, M.,Kakei, H.,Taya, N.,Kawasaki, M.,Sumi, H.,Yabuki, M.,Iwai, K.,Yoshida, S.,Yoshimatsu, M.,Aoyama, K.,Kosugi, Y.,Kojima, T.,Morishita, N.,Dougan, D.R.,Snell, G.P.,Imamura, S.,Ishikawa, T. Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2-a]pyrazine Scaffold as a Novel Proline Mimetic. J.Med.Chem., 56:1228-1246, 2013 Cited by PubMed: 23298277DOI: 10.1021/jm301674z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.84 Å) |
Structure validation
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