4HXM

Brd4 Bromodomain 1 complex with N-{3-(2-OXO-2,3-DIHYDRO-1,3-THIAZOL-4-YL)-5-[(THIOPHEN-2-YLSULFONYL)AMINO]PHENYL}BUTANAMIDE inhibitor

Summary for 4HXM

Entry DOI	10.2210/pdb4hxm/pdb
Related	4HXK 4HXL 4HXN 4HXO 4HXP 4HXR 4HXS
Descriptor	Bromodomain-containing protein 4, N-{3-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)-5-[(thiophen-2-ylsulfonyl)amino]phenyl}butanamide (3 entities in total)
Functional Keywords	brd4, bromodomain, four alpha helices, protein binding-inhibitor complex, protein binding/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus (By similarity): O60885
Total number of polymer chains	1
Total formula weight	15177.60
Authors	Chen, T.T.,Cao, D.Y.,Chen, W.Y.,Xiong, B.,Shen, J.K.,Xu, Y.C. (deposition date: 2012-11-12, release date: 2013-04-03, Last modification date: 2024-02-28)
Primary citation	Zhao, L.,Cao, D.,Chen, T.,Wang, Y.,Miao, Z.,Xu, Y.,Chen, W.,Wang, X.,Li, Y.,Du, Z.,Xiong, B.,Li, J.,Xu, C.,Zhang, N.,He, J.,Shen, J. Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain. J.Med.Chem., 56:3833-3851, 2013 Cited by PubMed: 23530754 DOI: 10.1021/jm301793a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation