4HWY

Trypanosoma brucei procathepsin B solved from 40 fs free-electron laser pulse data by serial femtosecond X-ray crystallography

Summary for 4HWY

• Entry DOI: 10.2210/pdb4hwy/pdb
• Descriptor: Cysteine peptidase C (CPC), beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: papain fold, lysosomal cysteine protease, hydrolase
• Biological source: Trypanosoma brucei brucei TREU927 (Trypanosoma brucei brucei strain 927/4 GUTat10.1)
• Total number of polymer chains: 1
• Total formula weight: 38270.63

Authors

Redecke, L.,Nass, K.,DePonte, D.P.,White, T.A.,Rehders, D.,Barty, A.,Stellato, F.,Liang, M.,Barends, T.R.M.,Boutet, S.,Williams, G.W.,Messerschmidt, M.,Seibert, M.M.,Aquila, A.,Arnlund, D.,Bajt, S.,Barth, T.,Bogan, M.J.,Caleman, C.,Chao, T.-C.,Doak, R.B.,Fleckenstein, H.,Frank, M.,Fromme, R.,Galli, L.,Grotjohann, I.,Hunter, M.S.,Johansson, L.C.,Kassemeyer, S.,Katona, G.,Kirian, R.A.,Koopmann, R.,Kupitz, C.,Lomb, L.,Martin, A.V.,Mogk, S.,Neutze, R.,Shoemann, R.L.,Steinbrener, J.,Timneanu, N.,Wang, D.,Weierstall, U.,Zatsepin, N.A.,Spence, J.C.H.,Fromme, P.,Schlichting, I.,Duszenko, M.,Betzel, C.,Chapman, H. (deposition date: 2012-11-09, release date: 2012-12-05, Last modification date: 2023-09-20)

• Primary citation: Redecke, L.,Nass, K.,DePonte, D.P.,White, T.A.,Rehders, D.,Barty, A.,Stellato, F.,Liang, M.,Barends, T.R.,Boutet, S.,Williams, G.J.,Messerschmidt, M.,Seibert, M.M.,Aquila, A.,Arnlund, D.,Bajt, S.,Barth, T.,Bogan, M.J.,Caleman, C.,Chao, T.C.,Doak, R.B.,Fleckenstein, H.,Frank, M.,Fromme, R.,Galli, L.,Grotjohann, I.,Hunter, M.S.,Johansson, L.C.,Kassemeyer, S.,Katona, G.,Kirian, R.A.,Koopmann, R.,Kupitz, C.,Lomb, L.,Martin, A.V.,Mogk, S.,Neutze, R.,Shoeman, R.L.,Steinbrener, J.,Timneanu, N.,Wang, D.,Weierstall, U.,Zatsepin, N.A.,Spence, J.C.,Fromme, P.,Schlichting, I.,Duszenko, M.,Betzel, C.,Chapman, H.N.; Natively inhibited Trypanosoma brucei cathepsin B structure determined by using an X-ray laser.; Science, 339:227-230, 2013; PubMed: 23196907; DOI: 10.1126/science.1229663

Experimental method

X-RAY DIFFRACTION (2.1 Å)