4HWT

Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor

Summary for 4HWT

Entry DOI	10.2210/pdb4hwt/pdb
Related	4HWO 4HWP 4HWR 4HWS
Descriptor	Threonine--tRNA ligase, cytoplasmic, ZINC ION, N-{[3-(2H-indazol-5-yl)phenyl]sulfonyl}-L-threoninamide, ... (4 entities in total)
Functional Keywords	aminoacyl-trna synthetase, protein-inhibitor complex, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P26639
Total number of polymer chains	2
Total formula weight	97831.84
Authors	Hilgers, M.T. (deposition date: 2012-11-08, release date: 2013-09-18)
Primary citation	Teng, M.,Hilgers, M.T.,Cunningham, M.L.,Borchardt, A.,Locke, J.B.,Abraham, S.,Haley, G.,Kwan, B.P.,Hall, C.,Hough, G.W.,Shaw, K.J.,Finn, J. Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design. J.Med.Chem., 56:1748-1760, 2013 Cited by PubMed: 23362938 DOI: 10.1021/jm301756m PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation